New NASDAQ Alert [Inside]

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New Alert: Tiziana Life Sciences Ltd (NASDAQ: TLSA)

TLSA is our new NASDAQ high volatility alert.

Over the past few days, TLSA rallied above its 50 day moving average of 0.49, presenting what could be the start of a new breakout opportunity.

If it continues to hold above its 50 day moving average, it could present increased upside potential. 

TLSA has a 200 day moving average of 0.61, more than 19% above yesterday’s close.

TLSA is a NASDAQ listed “clinical-stage biopharmaceutical company developing breakthrough therapies”.

TLSA uses “transformational drug delivery technologies to enable alternative routes of immunotherapy”. 

The company’s “innovative nasal approach has the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous (IV) delivery”. 

TLSA’s “lead candidate, intranasal foralumab, which is the only fully human anti-CD3 mAb, has demonstrated a favorable safety profile and clinical response in patients in studies to date”. 

Furthermore, the company’s “technology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline applications”.

As the company further explains: 

“Activated T cells play an important role in the inflammatory process.”

“Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb), binds to the T cell receptor and dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets.” 

In addition: 

“This effect has been demonstrated in patients with COVID and with multiple sclerosis, as well as in healthy normal subjects.” 

Importantly:

“The non-active SPMS intranasal foralumab Phase 2 trial dosed its first patient in December of 2023.”

“Immunomodulation by nasal anti-CD3 mAb represents a novel avenue for treatment of neuroinflammatory and neurodegenerative human diseases.”

Sadly, “Multiple sclerosis (MS) is one of the most widespread disabling neurological conditions of young adults around the world”.

“Recent findings from the National MS Society estimate that nearly 1 million people in the United States are living with MS”.

TLSA has announced multiple accomplishments recently that could be growth catalysts.

Earlier this year, the company announced:

“Tiziana Life Sciences Files New Patent Application for Combination Therapy of anti-CD3 (Foralumab) with GLP-1 Receptor Agonist for Additional Reduction of Obesity – Associated Inflammation”

Here are some of the company’s comments from this press release:

“Gabriele Cerrone, Chairman, acting CEO and founder of Tiziana Life Sciences said, “I believe that our commitment to improving patient outcomes by using anti-CD3, or foralumab, in risk mitigation for MACE could be another exciting indication for foralumab. We hope our efforts will give a new therapeutic option to patients afflicted with Type 2 Diabetes and non T2D obesity that are receiving GLP-1 receptor antagonists. We believe the risk reduction could be substantial with combination therapy.””

In addition, the company also announced:

“Tiziana Life Sciences Announces Updated Clinical and PET Scan Findings for Intranasal Foralumab in Two New Multiple Sclerosis Patients”

Here are some of the comments from this press release:

“The EA patient having a qualitative improvement in their PET scan also improved in their Modified Fatigue Impact Scale,” stated Dr. Tanuja Chitnis, M.D., Principal Investigator and Professor of Neurology at Harvard Medical School and senior neurologist at Brigham and Women’s Hospital. “Six out of the eight na-SPMS EA patients studied so far have seen measurable clinical improvement in their fatigue. I am excited to lead the effort to replicate these findings in the ongoing Phase 2 dose-ranging, randomized, placebo-controlled clinical trial.”

In March, the company announced:

“Tiziana Life Sciences Announces Podium Presentation at AD/PD of Nasal Anti-CD3 in Alzheimer’s Disease”

Here are the highlights from this press release:

• “Data shows reduction of microglia activation and improvement in behavior in rodent models of Alzheimer’s disease (AD) and Parkinson’s disease (PD)”
• “Nasal anti-CD3 reduced hemorrhage and edema that occurs with ARIA based on animal studies”
• “Neuroinflammation modulation may be synergistic to approved treatments in Alzheimer’s Disease”

Here are some of the company’s comments from this press release: 

“With the focus on effective Alzheimer’s disease treatments and we have the potential to be a novel, first in class neuroinflammatory modulator,” commented Gabriele Cerrone, Chairman, acting CEO and founder of Tiziana Life Sciences. “Our intranasal approach has large potential as it does not target beta-amyloid or other proteins, but focuses on the neuroinflammatory process itself, which may be complementary or synergistic with existing FDA approved treatments. The data also excitingly shows a reduction of hemorrhage and edema that occurs with ARIA.”

Last week, the company announced:

“Tiziana Life Sciences Announces Platform Presentation of New Quantitative PET Imaging Data on Foralumab at the Annual Meeting of the American Academy of Neurology”

“NEW YORK, April 11, 2024 (GLOBE NEWSWIRE) — Tiziana Life Sciences Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough neuro-immunomodulation therapies, today announced an upcoming oral presentation, titled, “Treatment of PIRA with Nasal Foralumab Dampens Microglial Activation and Stabilizes Clinical Progression in Non-Active Secondary Progressive MS” that will be presented during the “Multiple Sclerosis: Therapeutics and Clinical Decision Making” session at the Annual Meeting of the American Academy of Neurology, to be held April 13-18, 2024 in Denver, Colorado.”

In addition, just this morning, the company announced breaking news that could be another growth catalyst:

• “Tiziana Life Sciences Announces New Quantitative PET Imaging Data on Foralumab at the Annual Meeting of the American Academy of Neurology”

TLSA could be positioned for high growth.

Make sure to do your own due diligence.

Sources: Healthline, PR1, PR2, PR3, PR4, PR5, PR6, Website, Chart

Happy Trading!

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